Opportunity Information: Apply for RFA NR 24 005
The National Institutes of Health (NIH) is offering the grant opportunity "Strategies to Improve Health Outcomes and Advance Health Equity in Rural Populations (R01 Clinical Trial Optional)" under funding opportunity number RFA-NR-24-005. This is a discretionary grant using the NIH R01 research project mechanism, and it supports studies that may include a clinical trial but do not have to. The overall aim is to fund research that leads to real, sustained improvements in health outcomes for people living in rural areas, with a clear focus on advancing health equity.
The core problem this opportunity is trying to address is that rural populations experience disproportionate health burdens, including high rates of morbidity and disability and high, increasing rates of premature death. NIH is emphasizing that meaningful improvements will require more than short-term programs or narrow clinical fixes. Instead, applicants are expected to target the underlying drivers of poor health in rural communities, particularly social determinants of health (SDOH). In practice, that means proposing interventions that are developed, adapted, or implemented to address factors like access to health care and supportive services, transportation barriers, economic instability, education and employment challenges, food insecurity, housing quality, broadband and technology access, and other community conditions that shape health and health care use.
The NOFO is especially interested in research that improves the access to interventions, as well as their acceptability and effectiveness in rural settings. Rural contexts often involve distinctive constraints and strengths, such as fewer nearby services, workforce shortages, long travel distances, limited specialty care, and uneven infrastructure, alongside strong social networks and community institutions. Because of this, NIH encourages a wide range of study designs and methods, including community-engaged research approaches that actively involve rural residents and local partners. Proposals that build on community strengths, local priorities, and trusted organizations (for example, clinics, schools, faith communities, tribal entities, and community-based organizations) align well with the intent of the opportunity, particularly when they show how engagement will improve feasibility, uptake, and sustainability.
Eligible applicants span many types of organizations. Public sector applicants can include state, county, and city or township governments, as well as special district governments and independent school districts. Higher education institutions are eligible across categories, including public and state-controlled institutions, private institutions, and several mission-focused institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions, along with Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Tribal eligibility includes federally recognized Native American tribal governments and Native American tribal organizations (including those other than federally recognized tribal governments). The opportunity also allows participation from public housing authorities/Indian housing authorities, nonprofits (both with and without 501(c)(3) status), for-profit organizations other than small businesses, and small businesses. The NOFO also notes that faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions may apply.
There are important restrictions related to foreign involvement. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply. In addition, non-domestic components of U.S. organizations are not eligible to apply, and foreign components (as defined in the NIH Grants Policy Statement) are not allowed. In other words, the work and applicant organization need to be U.S.-based without foreign components included under NIH definitions.
From an administrative and funding standpoint, the listing indicates an award ceiling of $500,000. The opportunity is categorized under Education and Health funding activities and references CFDA numbers 93.242, 93.307, 93.361, and 93.846. The original closing date listed is 2024-05-17, and the opportunity record shows a creation date of 2024-03-06. Overall, this NOFO is designed for applicants who can propose rigorous, context-aware intervention research that directly tackles social and structural conditions driving rural health disparities, while demonstrating practical pathways to improve equity, access, and outcomes in rural communities.Apply for RFA NR 24 005
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Strategies to Improve Health Outcomes and Advance Health Equity in Rural Populations (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.307, 93.361, 93.846.
- This funding opportunity was created on 2024-03-06.
- Applicants must submit their applications by 2024-05-17. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "Strategies to Improve Health Outcomes and Advance Health Equity in Rural Populations (R01 Clinical Trial Optional)".
What is the funding opportunity number?
The funding opportunity number is RFA-NR-24-005.
Which agency is offering this grant?
This grant opportunity is offered by the National Institutes of Health (NIH).
What type of grant mechanism is being used?
NIH is using the R01 research project mechanism for this opportunity.
Is this a discretionary grant?
Yes. The listing describes this as a discretionary grant.
Are clinical trials required for this R01?
No. The opportunity is labeled "Clinical Trial Optional", meaning a proposed study may include a clinical trial but does not have to.
What is the overall aim of this opportunity?
The overall aim is to fund research that produces real, sustained improvements in health outcomes for people living in rural areas, with a clear focus on advancing health equity.
What problem is NIH trying to address through this NOFO?
This opportunity targets disproportionate health burdens experienced by rural populations, including high rates of morbidity and disability and high, increasing rates of premature death.
What kind of approaches does NIH want applicants to avoid?
NIH emphasizes that meaningful improvements in rural health will require more than short-term programs or narrow clinical fixes. Applicants are expected to address deeper, underlying drivers of poor health in rural communities.
What does NIH expect applicants to target in their interventions?
Applicants are expected to target underlying drivers of poor health, particularly social determinants of health (SDOH) and related social and structural conditions that shape health and health care use in rural settings.
What are examples of social determinants of health (SDOH) mentioned in the opportunity?
The NOFO highlights factors such as:
- Access to health care and supportive services
- Transportation barriers
- Economic instability
- Education and employment challenges
- Food insecurity
- Housing quality
- Broadband and technology access
- Other community conditions that shape health and health care utilization
What types of research outcomes does NIH appear to prioritize?
Based on the description, NIH is prioritizing research that improves health outcomes and advances health equity in rural populations, including work that strengthens access, acceptability, and effectiveness of interventions in rural settings.
Does NIH encourage specific study designs or methods?
Yes. NIH encourages a wide range of study designs and methods, including community-engaged research approaches that actively involve rural residents and local partners.
Why does NIH emphasize rural context in this NOFO?
The opportunity notes that rural settings can involve distinctive constraints and strengths, including fewer nearby services, workforce shortages, long travel distances, limited specialty care, and uneven infrastructure, alongside strengths such as strong social networks and community institutions. NIH wants interventions and implementation plans that are realistic for these conditions.
What does NIH mean by improving access, acceptability, and effectiveness in rural settings?
NIH signals interest in research that helps ensure interventions can be reached and used by rural populations (access), are appropriate and acceptable in rural communities (acceptability), and produce meaningful results in real-world rural conditions (effectiveness).
Are community partnerships encouraged?
Yes. The opportunity aligns well with proposals that build on community strengths, local priorities, and partnerships with trusted organizations to improve feasibility, uptake, and sustainability.
What types of local or trusted organizations are mentioned as potential partners?
Examples listed include clinics, schools, faith communities, tribal entities, and community-based organizations.
Who is eligible to apply?
A wide range of U.S.-based organizations are eligible, including public sector entities, higher education institutions (including mission-focused categories), tribal governments and organizations, nonprofits, for-profit organizations (with limits noted), small businesses, and other specified U.S. entities.
Which government entities are eligible applicants?
Eligible public sector applicants can include state governments, county governments, city or township governments, special district governments, and independent school districts.
Are colleges and universities eligible to apply?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are Historically Black Colleges and Universities (HBCUs) eligible?
Yes. HBCUs are explicitly included among eligible institution types.
Are Hispanic-serving Institutions (HSIs) eligible?
Yes. Hispanic-serving Institutions are explicitly included among eligible institution types.
Are Tribally Controlled Colleges and Universities (TCCUs) eligible?
Yes. Tribally Controlled Colleges and Universities (TCCUs) are explicitly included.
Are Alaska Native and Native Hawaiian Serving Institutions eligible?
Yes. The opportunity lists Alaska Native and Native Hawaiian Serving Institutions as eligible.
Are AANAPISIs eligible?
Yes. Asian American Native American Pacific Islander Serving Institutions (AANAPISIs) are listed as eligible.
Are tribal governments or tribal organizations eligible?
Yes. Eligible tribal applicants include federally recognized Native American tribal governments and Native American tribal organizations, including those other than federally recognized tribal governments.
Are nonprofits eligible to apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status are listed as eligible.
Are for-profit organizations eligible to apply?
Yes. The NOFO allows for-profit organizations other than small businesses, and it also separately lists small businesses as eligible.
Are faith-based organizations eligible to apply?
Yes. The NOFO notes that faith-based organizations may apply.
Are community-based organizations eligible to apply?
Yes. The NOFO notes that community-based organizations may apply.
Are public housing authorities eligible?
Yes. The NOFO includes public housing authorities/Indian housing authorities as eligible.
Are U.S. territories or possessions eligible to apply?
Yes. The opportunity notes that U.S. territories or possessions may apply.
Are eligible federal agencies allowed to apply?
Yes. The NOFO indicates that eligible federal agencies may apply.
Can a foreign (non-U.S.) organization apply for this grant?
No. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply.
Can a U.S. organization include a non-domestic component?
No. The NOFO states that non-domestic components of U.S. organizations are not eligible to apply.
Are foreign components allowed in the proposed project?
No. The NOFO states that foreign components (as defined in the NIH Grants Policy Statement) are not allowed.
What does this mean for where the work must be performed?
Based on the restrictions described, the applicant organization and the work supported by the award need to be U.S.-based and should not include foreign components under NIH definitions.
What is the award ceiling listed for this opportunity?
The listing references an award ceiling of $500,000.
What funding activity categories are associated with this opportunity?
The opportunity is categorized under Education and Health funding activities.
Which CFDA numbers are associated with this opportunity?
The description references CFDA numbers 93.242, 93.307, 93.361, and 93.846.
What is the original closing date listed?
The original closing date listed is 2024-05-17.
What is the opportunity record creation date?
The opportunity record shows a creation date of 2024-03-06.
What kinds of proposals best align with the intent of this NOFO?
Based on the description, proposals that best align are those that are rigorous and context-aware, focus on intervention research, directly tackle social and structural drivers of rural health disparities, and show practical pathways to improve equity, access, and health outcomes in rural communities.
Does the NOFO encourage building on existing community strengths?
Yes. The NOFO explicitly notes that rural communities may have strengths such as strong social networks and community institutions, and it encourages approaches that build on these strengths to support feasibility, uptake, and sustainability.
Is sustainability mentioned as an important consideration?
Yes. The description emphasizes the goal of real, sustained improvements and notes that community engagement and trusted partnerships can improve sustainability of interventions in rural settings.
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