Opportunity Information: Apply for PA 18 652
The National Institutes of Health (NIH) funding opportunity PA-18-652, titled "Developmentally Tailored HIV Prevention and Care Research for Adolescents and Young Adults (R21 Clinical Trial Not Allowed)," supports exploratory research that improves how HIV prevention and treatment are understood and delivered for adolescents and emerging adults. The central idea is that people in these age ranges are not a single uniform group, so research should be developmentally informed and tailored to the realities of adolescent and young adult growth, identity formation, relationships, cognition, and changing social environments. The announcement encourages investigators to use insights from modern developmental science to better explain HIV-related risk, prevention uptake, engagement in care, and treatment outcomes in this heterogeneous population.
This specific announcement uses the NIH R21 mechanism, which is designed for early-stage, innovative, and potentially high-impact projects that may not yet have extensive preliminary data. That makes it a good fit for high risk/high payoff ideas, projects that test new conceptual models, or studies that rely on secondary analyses of existing datasets to generate novel developmental hypotheses. The "Clinical Trial Not Allowed" designation means applicants cannot propose studies that meet the NIH definition of a clinical trial (for example, prospectively assigning people to an intervention to assess outcomes). Instead, the emphasis is on exploratory, hypothesis-generating, mechanistic, observational, methodological, or analytic work that can set up future intervention development or testing under a different mechanism or FOA.
The broader program area also references related mechanisms (R01 and R34) to help applicants choose the right pathway depending on readiness. In practical terms, R21 is positioned for projects still building the evidence base or testing new directions; R01 is more appropriate for applicants with stronger preliminary data and/or plans for more extensive or longitudinal analyses; and R34 is intended for developing and pilot testing interventions (though that is not the purpose of this R21-only clinical trial-not-allowed announcement). In other words, NIH is signaling a pipeline: discovery and early exploration (R21), deeper and more definitive research (R01), and preparation for intervention trials (R34), with applicants selecting the mechanism that matches the maturity of their work.
The funding instrument is a discretionary grant within the education and health activity categories, and it is associated with CFDA numbers 93.242, 93.279, and 93.855, reflecting NIH program areas that can include mental health, substance use, and broader biomedical/behavioral health research intersecting with HIV. The listed award ceiling is $200,000 (as provided in the source data). The original closing date shown in the record is January 7, 2021, and the opportunity record was created on February 12, 2018, indicating this was part of an NIH multi-year posting cycle with defined submission windows.
Eligibility is broad and includes many types of organizations that commonly apply to NIH, such as state, county, and local governments; special district governments; independent school districts; public and state-controlled and private institutions of higher education; Native American tribal governments (federally recognized) and tribal organizations (including those other than federally recognized governments); public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses) and small businesses; and other entities. The announcement also explicitly highlights additional eligible applicant types and communities, including Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISI); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); eligible federal agencies; faith-based or community-based organizations; U.S. territories or possessions; regional organizations; and non-U.S. entities (foreign organizations). This breadth signals an interest in supporting work across diverse settings and populations, including those disproportionately affected by HIV or underserved by traditional research infrastructure.
Overall, PA-18-652 is aimed at accelerating new, developmentally grounded knowledge about HIV prevention and care for adolescents and young adults, with the R21 mechanism supporting innovative, exploratory studies that can open new directions, refine developmental frameworks, and build a foundation for later-stage research and intervention development, while avoiding clinical trial designs under this specific announcement.Apply for PA 18 652
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Developmentally Tailored HIV Prevention and Care Research for Adolescents and Young Adults (R21 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.279, 93.855.
- This funding opportunity was created on 2018-02-12.
- Applicants must submit their applications by 2021-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Funding Opportunity |
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| Basic Research in Cancer Health Disparities (R21 Clinical Trial Not Allowed) Apply for PAR 18 655 Funding Number: PAR 18 655 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Basic Research in Cancer Health Disparities (R01 Clinical Trials Not Allowed) Apply for PAR 18 654 Funding Number: PAR 18 654 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploiting Omics Assays to Investigate Molecular Regulation of Persistent HIV in Individuals with Substance Use Disorder (R61/R33 Clinical Trial Optional) Apply for RFA DA 19 003 Funding Number: RFA DA 19 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| U.S. Tobacco Control Policies to Reduce Health Disparities (R01 Clinical Trial Optional) Apply for PAR 18 675 Funding Number: PAR 18 675 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| U.S. Tobacco Control Policies to Reduce Health Disparities (R21 Clinical Trial Optional) Apply for PAR 18 674 Funding Number: PAR 18 674 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Epidemiologic Research on Emerging Risk Factors and Liver Cancer Susceptibility (R21 - Clinical Trial Not Allowed) Apply for PA 18 678 Funding Number: PA 18 678 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Epidemiologic Research on Emerging Risk Factors and Liver Cancer Susceptibility (R01 - Clinical Trial Not Allowed) Apply for PA 18 677 Funding Number: PA 18 677 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Fundamental Mechanisms of Affective and Decisional Processes in Cancer Control (R01 Clinical Trial Optional) Apply for PAR 18 681 Funding Number: PAR 18 681 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Short-term Mentored Career Enhancement Awards for Mid-Career Investigators to Integrate Basic Behavioral and Social Sciences (K18 Clinical Trial Required) Apply for PAR 18 692 Funding Number: PAR 18 692 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Science-Based Quality Measurement and Management Development for Opioid Use Disorder Treatment (R61/R33 Clinical Trial Required) Apply for RFA DA 19 005 Funding Number: RFA DA 19 005 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| SBIR Technology Transfer (R43/R44 Clinical Trial Not Allowed) Apply for PA 18 705 Funding Number: PA 18 705 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Research Answers to National Cancer Institute's (NCI) Provocative Questions (R01 Clinical Trial Optional) Apply for RFA CA 18 019 Funding Number: RFA CA 18 019 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Research Answers to National Cancer Institute's (NCI) Provocative Questions (R21 Clinical Trial Optional) Apply for RFA CA 18 020 Funding Number: RFA CA 18 020 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Advancing Exceptional Research on HIV/AIDS and Substance Abuse (R01, Clinical Trial Optional) Apply for RFA DA 18 022 Funding Number: RFA DA 18 022 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Coordinating Center to Support NIDA Rural Opioid HIV and Comorbidity Initiative (U24 - Clinical Trial Not Allowed) Apply for RFA DA 19 004 Funding Number: RFA DA 19 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Fogarty HIV Research Training Program for Low-and Middle-Income Country Institutions (D43 Clinical Trial Optional) Apply for PAR 18 717 Funding Number: PAR 18 717 Agency: National Institutes of Health Category: Education, Health Funding Amount: $280,000 |
| Workshop on the Use of Adolescent Brain Cognitive Development (ABCD) Data (R25 Clinical Trial Not Allowed) Apply for RFA DA 19 006 Funding Number: RFA DA 19 006 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Improving Patient Adherence to Treatment and Prevention Regimens to Promote Health (R21 Clinical Trial Optional) Apply for PA 18 723 Funding Number: PA 18 723 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Improving Patient Adherence to Treatment and Prevention Regimens to Promote Health (R01 Clinical Trial Optional) Apply for PA 18 722 Funding Number: PA 18 722 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer Research (R21 Clinical Trial Not Allowed) Apply for PAR 18 731 Funding Number: PAR 18 731 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
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