Opportunity Information: Apply for PAR 23 171
The Diagnostic Centers of Excellence (X01 Clinical Trial Not Allowed) opportunity (PAR 23 171) is a National Institutes of Health (NIH) funding announcement designed to plug investigators and clinical sites into shared, centralized resources that support the next phase of the Undiagnosed Diseases Network (UDN). Rather than primarily paying an applicant to build a standalone program from scratch, this mechanism is focused on enabling access to an existing backbone of support operated by the Data Management Coordinating Center for Diagnostic Centers of Excellence (referenced as RFA-NS-22-051). In practical terms, the award is meant to help a new network of clinical sites deliver diagnostic services for patients with challenging, unresolved conditions by using common infrastructure, coordinated data systems, and standardized clinical research support.
A central feature of the FOA is the provision of network-level resources: infrastructure to run complex, multi-site diagnostic efforts; data management capabilities to capture, curate, harmonize, and share information across sites; and clinical research support to help participating centers operate consistently within the network. The overall goal is to improve the ability of clinical programs to evaluate patients with undiagnosed diseases by making sure participating sites are not operating in isolation, and by ensuring that data produced through these evaluations can be managed and coordinated in a uniform way across the network. This aligns with the UDN mission of accelerating diagnosis and knowledge generation for rare and previously undiagnosed conditions, where progress often depends on pooling expertise, cases, and high-quality structured data.
This FOA is explicitly labeled "Clinical Trial Not Allowed," which signals that applications proposing clinical trials as defined by NIH will not be accepted under this mechanism. The emphasis is on diagnostic evaluation and associated clinical research support activities within a coordinated network context, not on interventional studies that assign participants to interventions to evaluate health-related outcomes. Applicants should read that restriction as a boundary on study design: projects need to fit within non-trial activities consistent with providing diagnostic services and related data and research coordination.
Eligibility is broad across government, academic, nonprofit, and private-sector organizations. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and Native American tribal organizations that are not federally recognized tribal governments. The FOA also allows public housing authorities/Indian housing authorities, nonprofits with and without 501(c)(3) status (so long as they are not institutions of higher education in that category listing), for-profit organizations other than small businesses, and small businesses. In addition to these standard categories, the announcement highlights "Other Eligible Applicants" such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments that are not federally recognized, and U.S. territories or possessions.
Foreign participation is constrained in a way that is typical for many NIH opportunities but is spelled out clearly here. Non-domestic (non-U.S.) entities (foreign organizations) and non-domestic (non-U.S.) foreign institutions are not eligible to apply as applicants, and non-domestic components of U.S. organizations are also not eligible to apply. However, "foreign components" are allowed as defined in the NIH Grants Policy Statement, meaning a U.S. applicant may include certain types of foreign involvement when it meets NIH's definition and requirements for a foreign component (for example, a discrete project element performed outside the U.S.), subject to NIH rules and approvals.
Administratively, the opportunity is categorized as discretionary and uses a grant funding instrument. It sits under a broad set of CFDA numbers (including 93.113, 93.121, 93.172, 93.233, 93.350, and several 93.8xx lines), reflecting NIH's multi-institute structure and the cross-cutting nature of undiagnosed and rare disease work. The opportunity was created on 2023-04-06, and the original closing date listed is 2025-05-15. The award ceiling and expected number of awards are not specified in the provided source data, which usually means applicants should consult the full FOA text and any related NIH guidance for budget expectations, scope, and how NIH anticipates making and structuring awards.
Overall, this announcement is best read as an entry point into an organized diagnostic network: it is for groups that want to participate in a coordinated system for evaluating undiagnosed disease patients, and that can benefit from shared data management and clinical research support rather than duplicating those capabilities locally. The value proposition is the ability to operate as part of a standardized, networked effort where cases, data, and diagnostic learning can be managed consistently and leveraged across multiple clinical sites.Apply for PAR 23 171
- The National Institutes of Health in the environment, health, income security and social services sector is offering a public funding opportunity titled "Diagnostic Centers of Excellence (X01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.233, 93.350, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.855, 93.865, 93.867.
- This funding opportunity was created on 2023-04-06.
- Applicants must submit their applications by 2025-05-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Frequently Asked Questions (FAQs)
What is the Diagnostic Centers of Excellence (X01 Clinical Trial Not Allowed) opportunity (PAR 23 171)?
This is a National Institutes of Health (NIH) funding announcement that supports Diagnostic Centers of Excellence by connecting investigators and clinical sites to shared, centralized network resources. It is designed to support the next phase of the Undiagnosed Diseases Network (UDN) by helping participating sites deliver diagnostic services for patients with challenging, unresolved conditions using common infrastructure, coordinated data systems, and standardized clinical research support.
What is the main purpose of this funding opportunity?
The purpose is to plug participating clinical sites into an existing backbone of support (operated by the Data Management Coordinating Center for Diagnostic Centers of Excellence, referenced as RFA-NS-22-051) rather than paying applicants primarily to build a standalone program from scratch. The focus is on enabling coordinated, multi-site diagnostic efforts supported by shared data management and harmonized processes.
How does this opportunity relate to the Undiagnosed Diseases Network (UDN)?
The opportunity supports the next phase of the UDN by strengthening the ability of clinical programs to evaluate patients with undiagnosed diseases in a coordinated way. It aligns with the UDN mission of accelerating diagnosis and knowledge generation for rare and previously undiagnosed conditions, where progress often depends on pooling expertise, cases, and high-quality structured data across sites.
What kinds of resources does the network provide to funded sites?
The FOA emphasizes network-level resources, including: (1) infrastructure to run complex, multi-site diagnostic efforts; (2) data management capabilities to capture, curate, harmonize, and share information across sites; and (3) clinical research support to help participating centers operate consistently within the network.
Is the funding meant to build a new program from scratch at the applicant site?
Not primarily. The mechanism is described as enabling access to an existing centralized backbone of support, with the intent that sites use shared infrastructure and coordinated systems rather than duplicating those capabilities locally.
What does "Clinical Trial Not Allowed" mean for applicants?
It means applications proposing clinical trials (as defined by NIH) will not be accepted under this mechanism. Applicants should treat this as a study design boundary: supported activities need to fit within non-trial activities consistent with providing diagnostic services and related data and research coordination, rather than interventional studies that assign participants to interventions to evaluate health-related outcomes.
Can an application include a clinical trial component?
No. The FOA is explicitly labeled "Clinical Trial Not Allowed," indicating that applications proposing NIH-defined clinical trials are not accepted under this opportunity.
If clinical trials are not allowed, what is the focus instead?
The focus is on diagnostic evaluation and associated clinical research support activities within a coordinated network context. The goal is to improve the ability of clinical programs to evaluate undiagnosed disease patients and ensure data from those evaluations can be uniformly managed and coordinated across the network.
Who can apply for this opportunity?
Eligibility is broad and includes government, academic, nonprofit, and private-sector organizations. Examples listed include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and tribal organizations that are not federally recognized tribal governments.
Are nonprofits eligible to apply?
Yes. The FOA allows nonprofits with and without 501(c)(3) status (as described in the opportunity information), as well as other eligible nonprofit categories noted in the announcement.
Are for-profit entities eligible to apply?
Yes. The eligibility list includes for-profit organizations other than small businesses, and it also includes small businesses.
Are institutions of higher education eligible?
Yes. Both public and state-controlled institutions of higher education and private institutions of higher education are included in the eligible applicant categories.
Are tribal governments and tribal organizations eligible?
Yes. The eligible categories include federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized tribal governments. The announcement also highlights Indian/Native American tribal governments that are not federally recognized among "Other Eligible Applicants."
Which "Other Eligible Applicants" are specifically highlighted?
The announcement highlights a range of other eligible applicants, including Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; Indian/Native American tribal governments that are not federally recognized; and U.S. territories or possessions.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are explicitly listed among the "Other Eligible Applicants" highlighted in the announcement.
Can a foreign organization apply as the main applicant?
No. Non-domestic (non-U.S.) entities (foreign organizations) and non-domestic (non-U.S.) foreign institutions are not eligible to apply as applicants under this opportunity.
Can a non-domestic component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are also not eligible to apply as applicants under this opportunity.
Are any types of foreign participation allowed at all?
Yes, but in a limited way. "Foreign components" are allowed as defined in the NIH Grants Policy Statement. This means a U.S. applicant may include certain types of foreign involvement when it meets NIH's definition and requirements for a foreign component (for example, a discrete project element performed outside the U.S.), subject to NIH rules and approvals.
What is the funding instrument type?
The opportunity uses a grant funding instrument.
How is the opportunity categorized administratively?
It is categorized as discretionary.
What are the CFDA numbers associated with this opportunity?
The opportunity is listed under multiple CFDA numbers, including 93.113, 93.121, 93.172, 93.233, 93.350, and several 93.8xx lines, reflecting NIH's multi-institute structure and the cross-cutting nature of undiagnosed and rare disease work.
When was this opportunity created?
The opportunity was created on 2023-04-06.
What is the closing date listed for this opportunity?
The original closing date listed is 2025-05-15.
Is there an award ceiling listed?
No. The award ceiling is not specified in the provided source information, which typically means applicants should consult the full FOA text and related NIH guidance for budget expectations and scope.
Is the expected number of awards provided?
No. The expected number of awards is not specified in the provided source information.
What is the overall value proposition for applicants?
The opportunity is best understood as an entry point into an organized diagnostic network. The value comes from being able to operate as part of a standardized, networked effort where cases, data, and diagnostic learning can be managed consistently and leveraged across multiple clinical sites, rather than each site operating in isolation.
What backbone resource is referenced as central to the program?
The FOA describes access to an existing backbone of support operated by the Data Management Coordinating Center for Diagnostic Centers of Excellence, which is referenced as RFA-NS-22-051.
What outcomes is the network trying to improve?
The stated goal is to improve the ability of clinical programs to evaluate patients with undiagnosed diseases by ensuring participating sites are not operating in isolation and by ensuring that data produced through evaluations can be managed and coordinated in a uniform way across the network.
Browse more opportunities from the same category: Environment, Health, Income Security and Social Services
Next opportunity: IIJA Bureau of Land Management Arizona Recreation and Visitor Services
Previous opportunity: NIJ FY23 National Study Examining Interpersonal Violence Experienced By Young Adults
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAR 23 171
Applicants also applied for:
Applicants who have applied for this opportunity (PAR 23 171) also looked into and applied for these:
| Funding Opportunity |
|---|
| Implementation Research on Noncommunicable Disease Risk Factors among Low- and Middle-Income Country and Tribal Populations Living in City Environments (R01 Clinical Trial Optional) Apply for PAR 23 319 Funding Number: PAR 23 319 Agency: National Institutes of Health Category: Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAR 23 171", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.