Opportunity Information: Apply for CDC RFA GH22 2272
The grant opportunity "Informing global polio eradication efforts through innovative modeling approaches" (Funding Opportunity Number CDC RFA GH22 2272) is a CDC cooperative agreement designed to strengthen the evidence base behind the Global Polio Eradication Initiative (GPEI) by expanding and diversifying the modeling tools used to guide policy and on-the-ground operations. It sits within the broader context of polio eradication as a long-standing, agency-wide CDC priority, supported through CDC's Emergency Operations Center activation for global polio response since 2011. The opportunity emphasizes that the world has moved from endemic wild poliovirus (WPV) circulation in 125 countries in 1988 to just two countries by 2021, with WPV types 2 and 3 already eradicated and only WPV type 1 remaining, concentrated in the WHO Eastern Mediterranean Region.
The core problem this funding aims to tackle is that the eradication "endgame" is no longer just about stopping WPV1 in Pakistan and Afghanistan; it is equally about managing the growing burden of circulating vaccine-derived polioviruses (cVDPVs). These cVDPVs emerge when the live, weakened virus used in oral poliovirus vaccine (OPV) spreads for long periods in under-immunized communities and genetically reverts toward neurovirulence. The announcement ties this directly to GPEI's Polio Eradication Strategy 2022-2026, which outlines how partners plan to address the final reservoirs of WPV1 and the expanding cVDPV threat, while also beginning practical planning for what a polio-free world should look like.
A major forward-looking feature of the opportunity is the focus on the post-certification era, especially the planned cessation of OPV use in routine immunization within about 12 months after WPV eradication is certified. The CDC highlights that the highest risk window for vaccine-derived poliovirus emergence is expected to be the first two years after OPV cessation, largely because population intestinal mucosal immunity that helps block transmission will decline over time. At the same time, the risk of accidental poliovirus reintroduction remains as long as live polioviruses are stored or handled in poliovirus-essential facilities (PEFs), such as vaccine manufacturers, where a containment breach could seed community or environmental transmission.
Within that landscape, the opportunity lays out a set of practical decision questions that modeling is expected to answer. On the near-term outbreak side, CDC is looking for statistical and mathematical models that can identify which factors, or combinations of factors, make field-level cVDPV outbreak response faster, more reliable, and more cost-effective. That points to models that can compare response strategies (for example, differing campaign timing, geographic targeting, vaccine choices, operational constraints, or coverage levels) and translate those comparisons into actionable guidance and cost implications. On the longer-term side, the grant seeks models that clarify what poliovirus surveillance should look like once WPV is gone: what mix of surveillance systems and activities is both sustainable and sensitive enough to detect VDPV emergence, how much those systems cost, and how to optimize surveillance in a world where the disease is rarer but the consequences of missing early transmission are severe. A special surveillance emphasis is included for countries hosting PEFs, where additional questions center on what surveillance package is needed around these facilities to ensure adequate sensitivity and early detection capacity in case of an accidental release.
The CDC frames this opportunity as an expansion of an established modeling partnership tradition, noting nearly 20 years of experience working with modelers through prior cooperative agreements to inform GPEI policy decisions. However, it argues that the current portfolio needs to broaden beyond existing approaches to better capture operational efficiency and cost-effectiveness at the field level, particularly for outbreak response and for surveillance design in the post-certification era. The cooperative agreement mechanism also signals that the CDC expects active collaboration rather than purely independent research, with the goal of producing decision-ready outputs that can directly inform program strategy and implementation.
Finally, the announcement explicitly links the scientific goals to workforce development. It describes a parallel need to grow the role of modeling in public health decision-making and to build modeling literacy among CDC staff. The opportunity encourages collaborative environments that can include hands-on training opportunities for students and early-career contributors, with an emphasis on translating analytical work into real-world action rather than leaving results in purely academic form.
From an administrative standpoint, this is a discretionary funding opportunity under the health activity category (CFDA 93.185) administered by the Department of Health and Human Services, Centers for Disease Control - Center for Global Health. Eligibility is broad, spanning federal-recognized tribal entities, state and local governments, public and private higher education institutions, nonprofits (including and excluding 501(c)(3)), and for-profit organizations including small businesses, among others. The expected number of awards is two, and applications were due May 6, 2022, via electronic submission by 11:59 pm ET. The listing shows an award ceiling of 0, which typically indicates that the ceiling was not specified in the synopsis and would need to be confirmed in the full announcement or related budget guidance.Apply for CDC RFA GH22 2272
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Informing global polio eradication efforts through innovative modeling approaches" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.185.
- This funding opportunity was created on Mar 07, 2022.
- Applicants must submit their applications by May 06, 2022 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification), Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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