Opportunity Information: Apply for CDC RFA GH22 2272
The grant opportunity "Informing global polio eradication efforts through innovative modeling approaches" (Funding Opportunity Number CDC RFA GH22 2272) is a CDC cooperative agreement designed to strengthen the evidence base behind the Global Polio Eradication Initiative (GPEI) by expanding and diversifying the modeling tools used to guide policy and on-the-ground operations. It sits within the broader context of polio eradication as a long-standing, agency-wide CDC priority, supported through CDC's Emergency Operations Center activation for global polio response since 2011. The opportunity emphasizes that the world has moved from endemic wild poliovirus (WPV) circulation in 125 countries in 1988 to just two countries by 2021, with WPV types 2 and 3 already eradicated and only WPV type 1 remaining, concentrated in the WHO Eastern Mediterranean Region.
The core problem this funding aims to tackle is that the eradication "endgame" is no longer just about stopping WPV1 in Pakistan and Afghanistan; it is equally about managing the growing burden of circulating vaccine-derived polioviruses (cVDPVs). These cVDPVs emerge when the live, weakened virus used in oral poliovirus vaccine (OPV) spreads for long periods in under-immunized communities and genetically reverts toward neurovirulence. The announcement ties this directly to GPEI's Polio Eradication Strategy 2022-2026, which outlines how partners plan to address the final reservoirs of WPV1 and the expanding cVDPV threat, while also beginning practical planning for what a polio-free world should look like.
A major forward-looking feature of the opportunity is the focus on the post-certification era, especially the planned cessation of OPV use in routine immunization within about 12 months after WPV eradication is certified. The CDC highlights that the highest risk window for vaccine-derived poliovirus emergence is expected to be the first two years after OPV cessation, largely because population intestinal mucosal immunity that helps block transmission will decline over time. At the same time, the risk of accidental poliovirus reintroduction remains as long as live polioviruses are stored or handled in poliovirus-essential facilities (PEFs), such as vaccine manufacturers, where a containment breach could seed community or environmental transmission.
Within that landscape, the opportunity lays out a set of practical decision questions that modeling is expected to answer. On the near-term outbreak side, CDC is looking for statistical and mathematical models that can identify which factors, or combinations of factors, make field-level cVDPV outbreak response faster, more reliable, and more cost-effective. That points to models that can compare response strategies (for example, differing campaign timing, geographic targeting, vaccine choices, operational constraints, or coverage levels) and translate those comparisons into actionable guidance and cost implications. On the longer-term side, the grant seeks models that clarify what poliovirus surveillance should look like once WPV is gone: what mix of surveillance systems and activities is both sustainable and sensitive enough to detect VDPV emergence, how much those systems cost, and how to optimize surveillance in a world where the disease is rarer but the consequences of missing early transmission are severe. A special surveillance emphasis is included for countries hosting PEFs, where additional questions center on what surveillance package is needed around these facilities to ensure adequate sensitivity and early detection capacity in case of an accidental release.
The CDC frames this opportunity as an expansion of an established modeling partnership tradition, noting nearly 20 years of experience working with modelers through prior cooperative agreements to inform GPEI policy decisions. However, it argues that the current portfolio needs to broaden beyond existing approaches to better capture operational efficiency and cost-effectiveness at the field level, particularly for outbreak response and for surveillance design in the post-certification era. The cooperative agreement mechanism also signals that the CDC expects active collaboration rather than purely independent research, with the goal of producing decision-ready outputs that can directly inform program strategy and implementation.
Finally, the announcement explicitly links the scientific goals to workforce development. It describes a parallel need to grow the role of modeling in public health decision-making and to build modeling literacy among CDC staff. The opportunity encourages collaborative environments that can include hands-on training opportunities for students and early-career contributors, with an emphasis on translating analytical work into real-world action rather than leaving results in purely academic form.
From an administrative standpoint, this is a discretionary funding opportunity under the health activity category (CFDA 93.185) administered by the Department of Health and Human Services, Centers for Disease Control - Center for Global Health. Eligibility is broad, spanning federal-recognized tribal entities, state and local governments, public and private higher education institutions, nonprofits (including and excluding 501(c)(3)), and for-profit organizations including small businesses, among others. The expected number of awards is two, and applications were due May 6, 2022, via electronic submission by 11:59 pm ET. The listing shows an award ceiling of 0, which typically indicates that the ceiling was not specified in the synopsis and would need to be confirmed in the full announcement or related budget guidance.Apply for CDC RFA GH22 2272
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Informing global polio eradication efforts through innovative modeling approaches" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.185.
- This funding opportunity was created on Mar 07, 2022.
- Applicants must submit their applications by May 06, 2022 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification), Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
FAQs: Informing global polio eradication efforts through innovative modeling approaches (CDC RFA GH22 2272)
What is the official title of this grant opportunity?
The opportunity is titled "Informing global polio eradication efforts through innovative modeling approaches."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is CDC RFA GH22 2272.
What type of funding mechanism is this?
This is a CDC cooperative agreement, which signals that CDC expects active collaboration with awardees (not purely independent research) to produce decision-ready outputs that can directly inform program strategy and implementation.
Which federal agency is offering and administering this opportunity?
The opportunity is administered by the Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC), Center for Global Health.
What is the program/assistance listing or CFDA number?
The assistance listing/CFDA number provided is 93.185.
What is the overall purpose of this cooperative agreement?
The purpose is to strengthen the evidence base behind the Global Polio Eradication Initiative (GPEI) by expanding and diversifying the modeling tools used to guide policy and on-the-ground operations related to polio eradication.
How does this opportunity fit into global polio eradication efforts?
It is positioned within polio eradication as a long-standing, agency-wide CDC priority and is aligned with CDC's global polio response posture, including the CDC Emergency Operations Center activation for global polio response since 2011.
What polio eradication strategy does the opportunity reference?
The announcement ties its goals to GPEI's Polio Eradication Strategy 2022-2026, including addressing final reservoirs of wild poliovirus type 1 (WPV1), tackling the expanding threat of circulating vaccine-derived polioviruses (cVDPVs), and planning for a polio-free world.
What problem is this funding trying to address right now?
The core problem is that the eradication "endgame" is not only about stopping remaining WPV1 transmission (concentrated in the WHO Eastern Mediterranean Region, specifically Pakistan and Afghanistan), but also about managing the growing burden of cVDPVs, which can emerge in under-immunized communities.
What are circulating vaccine-derived polioviruses (cVDPVs), as described in the announcement?
cVDPVs can emerge when the live, weakened virus used in oral poliovirus vaccine (OPV) spreads for long periods in under-immunized communities and genetically reverts toward neurovirulence, creating a transmission and outbreak risk.
Why is the "post-certification era" a focus of this opportunity?
The opportunity emphasizes the period after WPV eradication is certified, including practical planning for what a polio-free world should look like and the risks and program decisions that remain once WPV is gone.
What does the opportunity say about OPV cessation?
It highlights planned cessation of OPV use in routine immunization within about 12 months after WPV eradication is certified.
When is the highest risk window for vaccine-derived poliovirus emergence expected after OPV cessation?
The highest risk window is expected to be the first two years after OPV cessation.
Why does risk increase after OPV cessation, according to the synopsis?
The synopsis notes that population intestinal mucosal immunity, which helps block transmission, will decline over time after OPV cessation, increasing vulnerability to emergence and spread if poliovirus is reintroduced or persists.
What are poliovirus-essential facilities (PEFs), and why do they matter in this opportunity?
PEFs are facilities that store or handle live polioviruses (such as vaccine manufacturers). The opportunity notes that the risk of accidental reintroduction remains as long as live polioviruses are stored or handled in these facilities, because a containment breach could seed community or environmental transmission.
What kinds of modeling does CDC want for near-term outbreak response?
CDC is looking for statistical and mathematical models that can identify which factors, or combinations of factors, make field-level cVDPV outbreak response faster, more reliable, and more cost-effective.
What kinds of outbreak-response decisions are models expected to help compare?
The announcement points to models that can compare response strategies such as campaign timing, geographic targeting, vaccine choices, operational constraints, and coverage levels, and translate comparisons into actionable guidance and cost implications.
What kinds of modeling does CDC want for longer-term surveillance planning?
The grant seeks models that clarify what poliovirus surveillance should look like once WPV is gone, including what mix of surveillance systems and activities is sustainable and sensitive enough to detect VDPV emergence, what those systems cost, and how to optimize surveillance when the disease is rarer but consequences of missing early transmission are severe.
Is there a special surveillance emphasis for any specific countries or contexts?
Yes. There is special emphasis for countries hosting poliovirus-essential facilities (PEFs), including modeling what surveillance package is needed around these facilities to ensure adequate sensitivity and early detection capacity in case of an accidental release.
How does this opportunity relate to CDC's prior modeling work?
CDC frames it as an expansion of an established modeling partnership tradition, citing nearly 20 years of experience working with modelers through prior cooperative agreements to inform GPEI policy decisions.
What gap or need is CDC trying to fill by expanding the modeling portfolio?
The announcement argues the current modeling portfolio needs to broaden beyond existing approaches to better capture operational efficiency and cost-effectiveness at the field level, particularly for outbreak response and for surveillance design in the post-certification era.
Does the opportunity include a workforce development or training component?
Yes. It explicitly links scientific goals to workforce development, describing a need to grow the role of modeling in public health decision-making and to build modeling literacy among CDC staff, including collaborative environments with hands-on training opportunities for students and early-career contributors.
What is the "health activity category" referenced for this opportunity?
The listing identifies it as a discretionary funding opportunity under the health activity category.
Who is eligible to apply, based on the synopsis?
Eligibility is broad and includes federal-recognized tribal entities, state and local governments, public and private higher education institutions, nonprofits (including and excluding 501(c)(3)), and for-profit organizations including small businesses, among others.
How many awards does CDC expect to make?
The expected number of awards is two.
When were applications due?
Applications were due May 6, 2022.
How were applications required to be submitted, and what was the deadline time zone?
The synopsis states applications were due via electronic submission by 11:59 pm ET.
What is the award ceiling for this opportunity?
The listing shows an award ceiling of 0. This typically indicates the ceiling was not specified in the synopsis and would need to be confirmed in the full announcement or related budget guidance.
Does the information provided specify the exact maximum funding amount per award?
No. Based on the synopsis alone, a specific maximum funding amount is not provided (the ceiling is listed as 0, suggesting it was not specified in the synopsis).
What does CDC ultimately want from the funded modeling work?
The synopsis emphasizes producing decision-ready outputs that can directly inform program strategy and implementation, rather than results that remain purely academic.
Browse more opportunities from the same category: Health
Next opportunity: Enhancing Disease Detection in Newborns: Building Capacity in Public Health Laboratories
Previous opportunity: Projects to Understand, Prevent, and Address Rising Gender-Based Violence in Eastern Europe and the Caucuses and the Nexus with Violent Extremism
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for CDC RFA GH22 2272
Applicants also applied for:
Applicants who have applied for this opportunity (CDC RFA GH22 2272) also looked into and applied for these:
| Funding Opportunity |
|---|
| Strengthening the Population & Public Health Workforce Pipeline Apply for CDC RFA OE22 2201 Funding Number: CDC RFA OE22 2201 Agency: Department of Health and Human Services, Centers for Disease Control - CSELS Category: Health Funding Amount: Case Dependent |
| Research on the Epidemiology, Prevention and Control of Influenza and Other Respiratory Viruses in India Apply for RFA IP 22 001 Funding Number: RFA IP 22 001 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $2,000,000 |
| US Platform to Measure Effectiveness of Seasonal Influenza, COVID-19 and other Respiratory Virus Vaccines for the Prevention of Acute Illness in Ambulatory Settings Apply for RFA IP 22 004 Funding Number: RFA IP 22 004 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $9,100,000 |
| Enhancing Disease Detection in Newborns: Building Capacity in Public Health Laboratories Apply for CDC RFA EH22 2201 Funding Number: CDC RFA EH22 2201 Agency: Department of Health and Human Services, Centers for Disease Control - NCEH Category: Health Funding Amount: $500,000 |
| Grants to Expand Substance Abuse Treatment Capacity in Adult and Family Treatment Drug Courts Apply for TI 22 010 Funding Number: TI 22 010 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $400,000 |
| Tribal Epidemiology Centers Public Health Infrastructure (TECPHI) Apply for CDC RFA DP22 2206 Funding Number: CDC RFA DP22 2206 Agency: Department of Health and Human Services, Centers for Disease Control - NCCDPHP Category: Health Funding Amount: $596,577 |
| Title X Family Planning Research Grants Apply for PA FPR 22 001 Funding Number: PA FPR 22 001 Agency: Department of Health and Human Services, Office of the Assistant Secretary for Health Category: Health Funding Amount: $750,000 |
| Infant and Early Childhood Mental Health Grant Program Apply for SM 22 006 Funding Number: SM 22 006 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $500,000 |
| Strengthening Civil Surgeons' Capacity to Improve LTBI Surveillance and Outcomes Among Status Adjusters Apply for CDC RFA PS22 2207 Funding Number: CDC RFA PS22 2207 Agency: Department of Health and Human Services, Centers for Disease Control - NCHHSTP Category: Health Funding Amount: Case Dependent |
| Hereditary Hemorrhagic Telangiectasia (HHT) Center Apply for HRSA 22 145 Funding Number: HRSA 22 145 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $2,000,000 |
| US Public Health Pathogens Genomics Centers of Excellence Apply for CDC RFA CK22 2204 Funding Number: CDC RFA CK22 2204 Agency: Department of Health and Human Services, Centers for Disease Control - NCEZID Category: Health Funding Amount: Case Dependent |
| Certified Community Behavioral Health Clinic (CCBHC)– Improvement and Advancement Grants Apply for SM 22 012 Funding Number: SM 22 012 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $1,000,000 |
| Certified Community Behavioral Health Clinic Expansion Grants Apply for SM 22 002 Funding Number: SM 22 002 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $1,000,000 |
| Advancing Surveillance of Violent Deaths Using the National Violent Death Reporting System (NVDRS) Apply for CDC RFA CE22 2201 Funding Number: CDC RFA CE22 2201 Agency: Department of Health and Human Services, Centers for Disease Control - NCIPC Category: Health Funding Amount: $962,085 |
| Transforming Pediatrics for Early Childhood (TPEC) Apply for HRSA 22 141 Funding Number: HRSA 22 141 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $1,000,000 |
| Provider’s Clinical Support System – Universities Apply for TI 22 011 Funding Number: TI 22 011 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $245,000 |
| Public Health Scholarship Program Apply for HRSA 22 122 Funding Number: HRSA 22 122 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Population-based Surveillance of Outcomes, Needs, and Well-being of Children and Adolescents with Congenital Heart Defects Apply for CDC RFA DD22 2203 Funding Number: CDC RFA DD22 2203 Agency: Department of Health and Human Services, Centers for Disease Control - NCBDDD Category: Health Funding Amount: $400,000 |
| Anti-doping Activities Apply for ANTI DOPING 2022 Funding Number: ANTI DOPING 2022 Agency: Office of National Drug Control Policy Category: Health Funding Amount: $15,000,000 |
| Money Follows the Person Demonstration Program Apply for CMS 1LI 22 001 Funding Number: CMS 1LI 22 001 Agency: Department of Health and Human Services, Centers for Medicare Medicaid Services Category: Health Funding Amount: $5,000,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "CDC RFA GH22 2272", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.