Opportunity Information: Apply for RFA AG 18 014
This funding opportunity, RFA-AG-18-014, is a limited-competition NIH cooperative agreement (U24; clinical trial not allowed) from the Department of Health and Human Services through the National Institutes of Health. It supports a single award (expected awards: 1) with an award ceiling of $750,000. The opportunity was created on September 27, 2017, with an original closing date of February 20, 2018. Eligible applicants are public and state-controlled institutions of higher education. The activity category is health, and it is associated with CFDA number 93.866.
The central purpose of the award is to fund a Data Coordinating Center (DCC) for the Accelerating Medicines Partnership Alzheimer’s Disease initiative, specifically the AMP-AD Target Discovery and Preclinical Validation Consortium. In practical terms, the DCC is meant to be the operational and technical backbone that enables the consortium to function as an open-science, systems-biology effort. Rather than funding new clinical studies, this announcement focuses on the infrastructure, coordination, and data-focused capabilities that allow multiple research teams to generate, harmonize, share, and analyze large-scale biomedical datasets efficiently and transparently.
A first major objective is "data enablement" for the consortium funded under the companion FOA (RFA-AG-18-013). That means the DCC is expected to help turn diverse research outputs into usable, well-documented, and interoperable data resources. Typical DCC responsibilities in initiatives like AMP-AD include setting data standards and submission requirements, managing data intake from consortium sites, performing quality control and curation, aligning metadata so datasets can be compared and integrated, tracking data provenance, and ensuring that data are packaged and released in ways that support broad reuse. The emphasis on systems biology implies the DCC should be able to support complex, multi-omic and multidimensional data types and make them easier to combine for network and pathway analyses, target discovery, and preclinical validation workflows.
A second major objective is to sustain and expand the "big-data infrastructure" of the AMP-AD Knowledge Portal. The Knowledge Portal is described as a collaborative research platform designed not only for the funded consortium but also for outside researchers and even citizen scientists. The intent is to create a robust, scalable environment where data and analytical outputs can be accessed, explored, and reused quickly, which accelerates translational learning. In this context, "sustain and expand" suggests maintaining reliable operations while continuously improving capacity, tooling, and usability so that the portal remains a high-value, community-facing resource for Alzheimer’s disease (AD) and AD-related dementias research.
The announcement also makes clear that the portal is meant to support rapid, iterative discovery leading toward predictive models of AD and related dementias. In other words, the DCC is expected to help the community move from raw and processed data toward reproducible analyses and model-building. That typically requires not just data hosting, but also thoughtful support for discoverability (search and indexing), documentation, versioning, and potentially shared computational resources or workflows that let users reproduce consortium analyses and build on them. The explicit mention of broad engagement (consortium members, researchers at large, citizen scientists) highlights an open-science orientation where data sharing, transparency, and ease of access are central outcomes, not secondary add-ons.
Because the funding instrument is a cooperative agreement (U24), the work is generally understood to be carried out in close coordination with NIH program staff and the broader AMP-AD governance structure. Cooperative agreements usually involve substantial involvement from the funding agency in setting priorities, coordinating across awardees, and ensuring that program-level milestones are met. For an applicant, that implies the DCC role is not just technical execution but also active participation in consortium coordination, aligning data releases with program goals, and supporting shared timelines and deliverables.
Overall, this opportunity is aimed at building and operating the data coordination and platform infrastructure that makes the AMP-AD Target Discovery and Preclinical Validation Consortium function effectively as a shared, open, big-data enterprise. The expected end result is a stronger AMP-AD Knowledge Portal and a smoother pipeline from consortium-generated datasets to community-accessible resources that enable faster target discovery, preclinical validation, and the development of predictive models relevant to Alzheimer’s disease and related dementias.Apply for RFA AG 18 014
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Data Coordinating Center for the Accelerating Medicines Partnership Target Discovery and Preclinical Validation Consortium AMP-AD DCC (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on Sep 27, 2017.
- Applicants must submit their applications by Feb 20, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education.
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